Rajendra Sharma
Medical Doctor, Tutor in Department of pharmacology
Title: Effect of Vitamin D supplementation in patients of moderate asthma undergoing treatment with inhaled corticosteroids
Biography
Biography: Rajendra Sharma
Abstract
Background: Vitamin D is an essential nutrient with significant immuno-modulatory effects. There is potential for a protective\r\nrole of vitamin D against etiopathogenesis of asthma and morbidity. This study evaluated the effect of vitamin D supplementation\r\nin patients with moderate asthma.\r\nAims & Objectives: To evaluate the effect of vitamin D supplementation on lung function improvement in patients of moderate\r\nasthma undergoing treatment with inhaled corticosteroids.\r\nMaterial & Methods: An interventional prospective study. A total of 60 patients of moderate asthma were enrolled in the study\r\nand randomly divided into two groups of 30 patients each. Group A: placed on steroid based treatment regimen (formoterol\r\n6 μg+budesonide 200 μg)+Vitamin D supplementation [60,000 IU/week for 8 consecutive weeks]. Group B: placed on steroid\r\nbased treatment regimen (formoterol 6 μg+budesonide 200 μg) only, as control. The enrolled patients were followed up for\r\n12 weeks and assessed for various parameters of disease severity, asthma control and improvement in lung function by using\r\nAsthma Control Test [ACT] questionnaire and pulmonary function tests (spirometry). Collected data was analyzed using\r\navailable statistical software [spss ver 20.0].\r\nResults: Statistically significant changes were seen in pre to post values of FEV1 [2.29±0.41 to 2.64±0.52], FVC [3.37±0.74\r\nto 3.61±0.76] and FEV1/FVC ratio [68.44±5.04 to 73.49±3.52] in Group A as well as in Group B, i.e., FEV1 [2.28±0.48 to\r\n2.65±0.53], FVC [3.36±0.68 to 3.58±0.76] and FEV1/FVC ratio [67.88±2.48 to 74.16±4.19]. However, there were no significant\r\ndifferences observed in pre and post values of FEV1, FVC and FEV1/FVC ratio in between the two groups.\r\nConclusion: Vitamin D supplementation failed to show additional benefits in lung function improvement in adults with\r\nmoderate asthma undergoing treatment with inhaled corticosteroids in the present study.