Wolfgang Lechner
CEO of different pharmacies in Austria and is now the Owner of a provincial pharmacy.
Title: Hospital-pharmacie, Compatibility of active components in parenteral infusions
Biography
Biography: Wolfgang Lechner
Abstract
Parenteral medication today is standard procedure in clinical therapy not only in hospitals but also in the ambulant and practicalrnsector. Extremely important is this kind of application for intensive care because it is the only way to provide medication andrnnutrition. Frequently, physicians and care personnel are not aware that drugs strongly differ in pH-value and solubility and arbitraryrnmixing can cause serious consequences and a worse outcome for the patients. Incompatibilities are unwanted physical-chemicalrnreactions of a drug with a solvent which take place before or during an application. These reactions are not to be mistaken as interactionsrnwhich change the effect of a drug by impact of another substance. Physical or “manifest†incompatibilities usually can be seen as arnchange of colour, separation, tarnish or precipitation caused by a change of proportion between ionisation and solubility. Chemical orrn“concealed†incompatibilities are characterized by chemical disintegration and macroscopically not recognizable. Analytical methodsrn(i.e., HPLC) have to be used. For a secure parenteral therapy critical or problematical situations have to be identified before thernapplication which is a major task for pharmacists with their widespread chemical-pharmaceutical knowledge. Our aim is to achieverna clearly arranged tool for the wards to enable the daily application of parenteral medication through central or peripheric-venousrncatheters in an easy and safe way.