Meha N Motiwala
Assistant Professor
Title: In vivo wound healing activity of Cajanus cajan on burn wound model in mice by regulating antioxidant and inflammatory mediators
Biography
Biography: Meha N Motiwala
Abstract
The leaves of Cajanus cajan has been traditionally used by Indian village people in wound healing, jaundice, hypocholestrolemiarnand inflammation. The phytoconstituents of C. cajan includes flavonoids and stilbenes. Wound healing is a complex process thatrnincludes inflammation, tissue formation, and remodeling. In order to scientifically prove the claimed utilization of the plant, therneffects of the extracts were investigated using burn wound model in mice including in vivo antioxidant and antimicrobial activity.rnHealing was assessed by the rate of wound contraction, period of epithelization and hydroxyproline content. The antimicrobial activityrnof extract was also studied against bacterial and fungal strain using agar dilution method. In vivo antioxidant activity was performedrnto understand the mechanism of wound healing potency. The result showed that C. cajan leaf extract has significant wound healingrnactivity as evident from the rate of wound contraction and epithelization. Hydroxyproline content was correlative with the healingrnpattern observed. C. cajan leaf extract treatment promote up-regulation of pro-inflammatory cytokines TNF-α during early phase ofrnwound healing, inhibit ROS accumulation and exhibit moderate antimicrobial activity. We propose induction of cytokine productionrnas one of the mechanism for acceleration of wound healing by C. cajan leaf extract which may be due to flavonoids and stilbenes