Driekus Grooff
professor
Title: Kinetic parameters from thermally stimulated dehydration and the relationship to drug-water interactions in pharmaceutical hydrates
Biography
Biography: Driekus Grooff
Abstract
A variety of Active Pharmaceutical Ingredients (API’s) can exist as hydrate forms. The conditions that facilitate hydrate formationrninclude factors such as humidity exposure during storage, pharmaceutical processing and dosage forms capable of transferringrnwater to API. It is mainly the thermodynamic water activity of the surrounding medium (solution, vapour phase, etc.) thatrndetermines whether a given hydrate structure can be formed. Studies that evaluate hydrate structure and stability will be beneficialrnto the understanding of hydrate formation and influence on physico-chemical properties. Thermal analysis has been widely used forrncharacterization of pharmaceutical hydrates in terms of structural and stability investigations. For hydrate compounds the use ofrnThermo-Gravimetric (TG) analysis had explored both isothermal and non-isothermal heating regimes for the investigation of thermallyrnstimulated dehydration kinetic parameters. Knowledge of dehydration kinetic parameters under a controlled heating program offerrnunique insight to drug-water association as the kinetic information mostly relate to structural features and intermolecular forcesrnoperating with the parent anhydrate drug form. This study report findings of dehydration kinetic parameters from two structurallyrnrelates macrolide antibiotics in an attempt to correlate observed kinetic behaviour to the structural characterization of the hydraterncompounds.