Subham Banerjee
Title: Lipid Nanoparticle Formulations (LNFs): A holistic drug delivery strategy for improving oral bio-availability of Antitubercular Drugs (ATDs)
Biography
Biography: Subham Banerjee
Abstract
LNFs have emerged as potential drug carriers to improve Gastrointestinal (GI) absorption and oral bioavailability of severalrnATDs, especially lipophilic drug like rifampicin. These lipid based nanoformulations may also be used for sustained drug releasernof such ATDs. The two newer generations of LNFs, namely, Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriersrn(NLCs) having capability as oral drug carriers to improve poor and variable oral bioavailability, poor GI absorption, solubilityrnand chemical instability related several issues associated with ATDs that has been perceived as a major bottleneck in successfulrntreatment of Tuberculosis (TB). In these regard, LNFs based drug delivery strategy has been a boon to current pharmacology andrnbiopharmaceutical enhancement of drug performance. Moreover, it is possible to design lipid based drug delivery systems capable ofrntargeting phagocytic cells which are infected by intracellular pathogens, such as mycobacteria. LNFs based delivery systems based onrnnanotechnology offer wide opportunities for improving the therapy for a range of diseases including TB.