Kailash Chandra Gupta
Professor
Title: Role of natural and functional polymers in drug delivery systems
Biography
Biography: Kailash Chandra Gupta
Abstract
Functional and smart polymers are currently playing a significant role in formulations of controlled drug delivery systems duernto their responsive behavior towards environmental stimuli. The delivery systems must be non-toxic, non-immunogenicrnand must be having optimum trapping and release properties for an active agent. To be more effective and economical therncontrolled devices should be able to release active agent in a control and site-specific manner. The physical and chemicalrnproperties of the polymers provide opportunities to design therapeutic devices for various applications. Though variousrndelivery systems based on electrical, mechanical and viral systems have been fabricated with great successes but these deliveryrnsystems have shown poor transfection efficiency and found to be immunogenic; hence delivery systems based on functionalrnpolymers such as poly (ethylene glycol) and dendric poly (amidoamine) found to be of great significance. The delivery systemsrnusing natural and biodegradable polymers such as chitosan, pectin and polysaccharides proved to be more are acceptable duernto their biocompatibility and biodegradability in physiological fluids in comparison to synthetic polymer systems. Consideringrnthe importance of natural polymers, the pH and ion responsive drug delivery systems have been designed using different formsrnand derivatives of the chitosan. These delivery systems have been tested for efficiency of loading and delivery of active agentsrnas a function of solution pH and ionic strength of the medium. The naturally occurring chitosan has provided enormousrnopportunities for controlling its properties to fabricate control site specific delivery systems. The degree of deacetylation inrnchitosan proved to be significant in controlling its stimuli responsive properties for drug delivery systems. The nano sizedrnchitosan delivery systems found to be more therapeutic in comparison to macro and micro sized delivery devices for controlledrnand sustained delivery of the active agents. The role of various parameters would be discussed and highlighted in this talk.