Satyendra Deka
Assam down town University, India
Title: Synthesis and characterization of some novel isoxazolines for In-vitro antiplatelet aggregation activity
Biography
Biography: Satyendra Deka
Abstract
A large number of medicinal compounds which have been discovered belong to a major class of heterocycles containing Nitrogen and Sulphur. Isoxazolines are five-member heterocyclic compound containing nitrogen and oxygen. Organic compounds containing 2-isoxazolines forms a significant group of drugs which exhibit an array of biological activities ranging from antibacterial, antifungal, diuretic, analgesic, anti-inflammatory, anti-tubercular, antitumor, anti pyretic, CNS depressants and so on. In view of the above observations we have synthesized 2-isoxazolines with various substitutions at fifth position. The starting material para-methoxy acetanilide (GSM) was synthesized by refluxing para anisidine with acetic anhydride for 30-45 min. GSM (01- 13) was synthesized by reacting GSM with various substituted aromatic benzaldehyde (01-13). The title compounds GSM (01a-13a) was synthesized by reacting GSM (01-13) with hydroxylamine hydrochloride. The newly synthesized compounds were characterized by MP, TLC, UV, IR, NMR and Mass spectra. The title compounds were screened for their in-vitro antiplatelet aggregating activity using Heparin as standard at concentration of 30, 50, 80 and 100μgm/ml. In conclusion, from the in-vitro antiplatelet activity results, it was observed that electron withdrawing groups on the aldehydic phenyl ring of the compounds influenced the activity. Among all the compounds tested, compounds GSM-03a, GSM-07a, GSM-12a with 2’-nitro, 2’-chloro, 4’-chloro substitution and GSM-11a with -H showed more significant activity. Compounds GSM-02a, GSM- 06a, GSM-08a with 3-nitro, 2-OH, 4-OH respectively showed mild to moderate activity compared to standard Heparin. Remaining compounds did not show any activity as compared to that of standard.