Suhas Narayan Sakarkar
Smt. Sharadchandrika Suresh Patil College of Pharmacy, India
Title: Impact of zeta potential on pharmaceuticals
Biography
Biography: Suhas Narayan Sakarkar
Abstract
Zeta potential is the surface charge of the particle, hence any interaction on the particle surface from external or internal environment leads to changes in surface properties and so the particle properties, which ultimately affects system stability. The zeta potential of the system depends on the adsorption and desorption properties of various drugs and excipients involved in the system. The stability of colloid or emulsion is dependent upon adsorption of ions (or polymers), chelating or complexing agents from the bulk of the suspending agent. Stability depends on the magnitude of zeta potential which depends on type on moiety, hydrocolloid, ionic/non-ionic surfactants. Further, the rate of change of zeta potential of the system with time is the major concern for determining the stability issues. Moreover, electrostatic interaction assists drug adsorption onto porous silicon nanoparticles, which can then be parenterally administered. Parenteral stability specifically depends on the composition of solution which is influenced by pH, ionic strength, types of buffers, protein concentration and the presence of various other additives. Systematic research in zeta potential led India to gain 1000$ research grant in seventies for cosmetic industries abroad. Investigations, for real time studies between dynamic environments of multicomponent systems by measuring zeta potential distributions of individual components and their mixtures is now on the recent trends. Hence, zeta potential is one of the essential tools for predicting the molecular interactions which assists in formulating more better formulations to meet the needs of global market.